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The Role of Smoking in the Pathogenesis of COPD The development and progression of COPD are characterized by airway inflammation and subsequent damage to the lung parenchyma

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These reactive metabolites cause oxidative stress, which has been shown to cause an increase in viral load and replication (Owe-Larsson et al., 2009)

Oral tobacco is a major form of tobacco addiction and can lead to the following [9]: Cancer of the oral cavity, oesophagus and pancreas due to the presence of at least 28 different cancer-causing substances found in chewing tobacco